SINCE WE GET ASKED THIS QUESTION OFTEN WE DID A COMPREHENSIVE COMPARISON BETWEEN CBD VS. PHENOBARBITAL


As with any medication the weight of the patient plays an vital  role in the dosing of the compound that you are treating with. Keeping in mind dogs and cats have a metabolic rate that exceeds ours by two-fold. Furthermore, as aforementioned, the weight and size of the dog is pertinent to the dosing protocol, but there are cases where these numbers may vary depending on the severity of the illness(es) presented. Dogs and cats contain an internal system that uses natural cannabinoids and their respective receptors to regulate and modulate a large part of the immune response and overall ability to promote health and combat disease. There are many herbs and medicinal foods that we have been consuming for centuries which act on the same system, the endocannabinoid system; Echinacea being one of them.

As we know, and as you will find in this document, there are many pharmaceutical drugs on the market that “treat” seizures, anxiety, and other various neurological disorders. But as with all synthetic drugs, there are further complications that can occur when you focus on simply masking the symptoms. Furthermore, these drugs contain no other positive beneifts, and render the animal treated, in a worse state than they were to begin with; are the seizures being managed? Well, sure, but what is the (intangible) cost? Whereas with CBD therapy, not only does this phytochemical have the potential to restore and boost neurological and immunological function, it can also add further nutritional support, making the only known side-effects, good ones.

Lets first use a dog with seizure symptoms (Most seize 10-20 times a month and more.) Here are a few things to take into immediate consideration:

Phenobarbital Half Life: 8-12 Hours max 6 in some cases (dogs metabolic rate is almost double a humans, therefore making their tolerance higher); making most common forms of synthetic medication need to be administered 2-4x daily.

CBD Half Life: 1-2 Days and in some cases studies show 3+. But since we’re talking about frequently occurring seizures, so admininstering once daily  initially and dosing down to 2 days- 3 days and so on, may help identify what the ideal dosage is for your particular dog and his or her particular form of illness..

Phenobarbital Cost:Lets use a 50 lb. dog as an example: 45mg dose of Phenobarbitol every 8-12 hours prescribed from a veterinarian (marked up cost, including office visits and follow-ups) of about  $4.00-$6.00, which would be $8.00-$12.00 in a 24 hour period; equating to an approximate $300 per month when using the (medial) cost.

CBD Cost:using the 50mg Dose for a 50lb dog at $139.95 per 7-Pack and dosing 1 syringe every other day (3ml/50mg Syringe) about $9.90 per dose, Making the monthly cost of ~$279.00/month.

So the CBD figures to be cheaper.  Don't forget some vets dose very high and have much larger mark ups on the per dose cost. This can range in the $500 and up mark. Of course we can set the dosage amount way higher and the cost would go up a bit but that wouldn't be necessary. Also once the CBD receptor is at capacity there is no further effect to added dose and this would be considered waste.


Now here’s the comparison of potential side-effects:


(Negative) Side Effects of CBD - NONE KNOWN
• (Negative) Side Effects of Phenobarbital Excessive thirst and urination and excessive appetite anxiety or depression or sedation when phenobarbital therapy is initiated. On occasion but rarely, anemia (lack of red blood cells) can occur a different seizure medication should be selected. Liver scarring, toxicity and failure with doses of 35mgs and up can occur. Proper monitoring should be done, this is another cost that’s incurred.
*By Wendy C. Brooks, DVM, DipABVP  Educational Director, VeterinaryPartner.com


Other Common Synthetic drugs prescribed for seizures and their side effects. Some very costly, and some nominal, but showing very little to no results. Clorazepate (Tranxene®) This medication is related to Diazepam (commonly known as Valium®), an excellent anti-seizure drug in emergencies. Contrary to what one might expect, in dogs the sustained-release formula does not last much longer than the regular formula. How long it actually does last is highly variable in a given patient and some dose experimentation may be needed before deciding if it works. Further, tolerance often develops to this drug so the dose may have to be increased as time passes. If you decide to discontinue its use, though, it must be tapered slowly off as sudden discontinuance can lead to withdrawal seizures.

Felbamate (Felbatol®) This drug has little potential for side effects but usually requires a three times per day dosing schedule and does not work well in puppies. The use of this medication typically costs between $100 and $200 per month for a larger dog. Because it does not have potential for sedation, it can also be used as the sole therapy for a dog with brain disease that causes a drowsy attitude (while other drugs might make this worse with their sedating properties).

Gabapentin (Neurontin®) This medication also requires dosing three to four times daily. On the plus side, it has little potential for side effects and reaches a stable blood level within the first week of administration. Some experts have been pleased with results on Gabapentin while others have not. Levetiracetam (Keppra®) This drug is popular for refractory epilepsy in dogs because it has been shown to be fairly reliable and has minimal side effects potential. Its disadvantages include expense (though several sizes are now available as generics, which helps tremendously) and the three times daily dosing schedule. Dosing may require some experimentation to hit on what is effective for a given patient.
Zonisamide (Zonegran) This drug is a sulfa class anti-seizure medication that is rapidly becoming a first-line treatment choice but might also be used to supplement more traditional therapies. Because it is a sulfa, it is vulnerable to the side effects associated with sulfa antibiotics: mostly tear production/dry eye issues but also some immune-mediated reactions. (Sulfa side effects are reviewed more completely in our pharmacy library under the sulfa antibiotics such as trimethoprim sulfa). Zonisamide can be used twice a day in dogs but lasts long enough in cats to possibly be used once daily.



The North American pet industry is on the rise and won’t seem to be losing any momentum anytime soon. The accessory sales volume is over the $14 Billion dollar mark and is projected to exceed $19 billion by 2020.  

The larger box retail stores seem to be making way for the smaller boutique chain stores.  Store owners say that with a smaller footprint they can focus on the products that make the most sense to the consumer.

Dog and cat owners are looking for natural options so it makes sense that there’s an influx of natural and holistic products taking over premium shelf space.

Natural/Medicinal hemp based and CBD (Cannabidiol) products are going to be the breakthrough item of 2016.

Press Release!!

KING KANINE, LLC and GREEN ROADShave partnered up to bring the best CBD product to the canine and feline market.         (King Kalm CBD™)  Green Roads’ uses a top of the line pharmaceutical-grade cannabidiol that is extracted from the industrial hemp plant.  This allows our products to be legal in all 50 states and creates no legal or regulatory hurdles surrounding Cannabis.

Phytocannabinoids are the herbal, natural, and classical cannabinoids found in the cannabis plant. There are over 60 cannabinoids that have been isolated from the plant. Tetrahydrocannabinol (THC), Cannabidiol (CBD) and Cannabinol (CBN) are the most prevalent.

Green Roads CEO is Laura Fuentes, a 24 year licensed Compounding Chemist, and PetExcelCBD’s formula is overseen by Dr. Joey Arena, A Homeopathic Board Certified Physician.

***Due to FDA Regulations, we advise you to research CBD on your own and visit our FACEBOOK PAGES and GREENROADSWORLD to read our testimonials & reviews on the results of our products.***